Also known as Dicloxacilina, Dicloxacillina, Dicloxacilline, Dicloxacillinum
A broad-spectrum, semi-synthetic, beta-lactam, penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Dicloxacillin binds to penicillin binding proteins (PBP) located on the inner membrane of the bacterial cell wall. It also inhibits the cross-linkage of peptidoglycan, a critical component of bacterial cell walls. This leads to the inhibition of bacterial cell wall synthesis and eventually causes cell lysis.
Originator: NCI Thesaurus | Source: The website of the National Cancer Institute (http://www.cancer.gov)
Can I take Dicloxacillin while breastfeeding?
Dicloxacillin is acceptable to use during breastfeeding and is frequently used to treat mastitis in nursing mothers.[1][2] Limited information indicates that dicloxacillin levels in milk are low and are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant’s gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated.
Drug levels
Maternal Levels. After a single oral dose of 250 mg of dicloxacillin in 2 women, milk levels ranged from 0.2 to 0.3 mg/L between 2 and 4 hours after the dose. The drug was undetectable in milk at 1 and 6 hours after the dose.[3]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in breastfed infants
Maternal Levels. After a single oral dose of 250 mg of dicloxacillin in 2 women, milk levels ranged from 0.2 to 0.3 mg/L between 2 and 4 hours after the dose. The drug was undetectable in milk at 1 and 6 hours after the dose.[3]
Infant Levels. Relevant published information was not found as of the revision date.
Possible effects on lactation
Relevant published information was not found as of the revision date.
References
1. Anon. ABM clinical protocol #4: mastitis. Revision, May 2008. Breastfeed Med. 2008;3:177-80. PMID: 18778213
2. Berth WL, Schauberger CW, Alvarado MA, Mathiason MA. Telephone-based management of lactation mastitis. J Reprod Med. 2009;54:291-4. PMID: 19517693
3. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732
Last Revision Date
20130907
Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
Source: LactMed – National Library of Medicine (NLM)