Also known as BPD-MA, Benzoporphyrin Derivative Monoacid Ring A, Verteporfina, Verteporfinum, Vertéporfine, Visudyne

A synthetic light-activated agent with photodynamic activity. Upon systemic administration, verteporfin accumulates in neovessels in the eye and, once stimulated by nonthermal red light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to neovascular endothelium and blood vessel occlusion. (NCI04)

Originator: NCI Thesaurus | Source: The website of the National Cancer Institute (http://www.cancer.gov)

Can I take Verteporfin while breastfeeding?

Limited information indicates that maternal verteporfin doses of 6 mg per square meter produce low levels in milk. Withholding breastfeeding for 24 to 48 hours after verteporfin administration should minimize risk to the breastfed infant.

Drug levels

Maternal Levels. According to the manufacturer, verteporfin and its diacid metabolite were found in the breastmilk of one woman after a 6 mg per square meter IV infusion. The verteporfin levels in breastmilk were up to 66% of the corresponding plasma levels and became unmeasurable (<2 mcg/L) within 24 hours. The diacid metabolite had lower peak breastmilk concentrations, but persisted up to at least 48 hours. Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Maternal Levels. According to the manufacturer, verteporfin and its diacid metabolite were found in the breastmilk of one woman after a 6 mg per square meter IV infusion. The verteporfin levels in breastmilk were up to 66% of the corresponding plasma levels and became unmeasurable (<2 mcg/L) within 24 hours. The diacid metabolite had lower peak breastmilk concentrations, but persisted up to at least 48 hours. Infant Levels. Relevant published information was not found as of the revision date.

Possible effects on lactation

Relevant published information was not found as of the revision date.

References

Last Revision Date

20131206

Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Source: LactMed – National Library of Medicine (NLM)