# Hydroxymethylglutaryl-CoA Reductase Inhibitors

Pitavastatin

Also known as Itavastatin, Pitavastatia, Pitavastatine, Pitavastatinum A novel statin that induces plaque regression and elevates HDL-cholesterol levels. Originator: NCI Thesaurus | Source: The website of the National Cancer Institute (http://www.cancer.gov) Can I...
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Rosuvastatin

A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a...
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Atorvastatin

The calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol...
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Fluvastatin

A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in...
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Simvastatin

Also known as MK 733, MK-733, Simvastatina, Simvastatine, Simvastatinum, Synvinolin, Zocor A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively...
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