Also known as 3,4-Dihydroxyphenethylamine, 3-Hydroxytyramine, Deoxyepinephrine, Dopamin, Dopamina, Dopamine Hydrochloride, Dopaminergic, Dopaminum, Dophamine, Hydroxytyramin, Hydroxytyramine, Oxytyramine

The hydrochloride salt form of dopamine, a monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- and beta-1- adrenergic receptors. Mediated through myocardial beta-1-adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1-adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output.

Originator: NCI Thesaurus | Source: The website of the National Cancer Institute (http://www.cancer.gov)

Can I take Dopamine while breastfeeding?

No information is available on the use of dopamine during breastfeeding. Because of its poor oral bioavailability and short half-life, any dopamine in milk is unlikely to affect the infant. Intravenous dopamine infusion may decrease milk production. Dopamine is known to reduce serum prolactin in nonnursing women, but no information is available on its effect on milk production in nursing mothers.

Drug levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Possible effects on lactation

Intravenous dopamine infusion in doses of 2 to 5 mcg/kg/minute given to nonnursing subjects and in women with hyperprolactinemia decreases serum prolactin concentrations.[1][2][3][4][5] However, relevant published information on the effect of intravenous dopamine on milk production in nursing mothers was not found as of the revision date. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Judd SJ, Rigg LA, Yen SS. The effects of ovariectomy and estrogen treatment on the dopamine inhibition of gonadotropin and prolactin release. J Clin Endocrinol Metab. 1979;49:182-4. PMID: 572372

2. Massara F, Camanni F, Vergano V et al. Inhibition of thyrotropin and prolactin secretion by dopamine in man. J Endocrinol Invest. 1978;1:25-30. PMID: 573767

3. Nicoletti I, Filipponi P, Sfrappini M et al. Catecholamines and pituitary function. I. Effects of catecholamine synthesis inhibition and subsequent catecholamine infusion on gonadotropin and prolactin serum levels in normal cycling women and in women with hyperprolactinemic amenorrhea. Horm Res. 1984;19:158-70. PMID: 6425187

4. Leblanc H, Lachelin GC, Abu-Fadil S, Yen SS. Effects of dopamine infusion on pituitary hormone secretion in humans. J Clin Endocrinol Metab . 1976;43:668-74. PMID: 956350

5. Crosignani PG , Reschini E, Peracchi M et al. Failure of dopamine infusion to suppress the plasma prolactin response to sulpiride in normal and hyperprolactinemic subjects. J Clin Endocrinol Metab. 1977;45:841-4. PMID: 410826

Last Revision Date

20150310

Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Source: LactMed – National Library of Medicine (NLM)

3D Model of the Dopamine molecule

MolView – data visualization platform