Also known as DL-Dobutamine, Dobutamin, Dobutamina, Dobutaminum, Racemic-dobutamine, rac-Dobutamine

A synthetic catecholamine with sympathomimetic activity. Dobutamine is a direct-acting inotropic agent and an adrenergic agonist that stimulates primarily the beta-1 adrenoceptor, with lesser effect on beta-2 or alpha receptors. Via beta-1 adrenoceptor of the heart, this agent induces positive inotropic effect with minimal changes in chronotropic activities or systemic vascular resistance. Dobutamine also causes vasodilation by stimulating beta-2 adrenergic receptors in blood vessels, augmented by reflex vasoconstriction resulting in increased cardiac output.

Originator: NCI Thesaurus | Source: The website of the National Cancer Institute (http://www.cancer.gov)

Can I take Dobutamine while breastfeeding?

No information is available on the use of dobutamine during breastfeeding. Because of its poor oral bioavailability and short half-life, any dobutamine in milk is unlikely to affect the infant.

Drug levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in breastfed infants

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Possible effects on lactation

Relevant published information in nursing mothers was not found as of the revision date. Unlike dopamine, dobutamine infusion does not affect serum prolactin concentration in infants[1] and in adult males.[2] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1. Filippi L, Pezzati M, Poggi C et al. Dopamine versus dobutamine in very low birthweight infants: endocrine effects. Arch Dis Child Fetal Neonatal Ed. 2007;92:F367-71. PMID: 17329276

2. Schilling T, Grundling M, Strang CM. Effects of dopexamine, dobutamine or dopamine on prolactin and thyreotropin serum concentrations in high-risk surgical patients. Intensive Care Med. 2004;30:1127-33. PMID: 15138671

Last Revision Date

20150310

Disclaimer:Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Source: LactMed – National Library of Medicine (NLM)

3D Model of the Dobutamine molecule

MolView – data visualization platform